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. 2019 Apr 23;9:6428. doi: 10.1038/s41598-019-41444-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mistletoe extracts exhibited anticancer effects in hepatocellular carcinoma Hep3B cells. The anti-proliferative effect of three mistletoe extracts in Hep3B cells (A). Hep3B cells were treated with different concentrations of Iscador Q (grown on oak trees), Iscador M (grown on maple trees), or Fraxini (grown on ash trees) for 72 hr. Data are mean ± SD of three separate experiments. (B) Fraxini reduced tumorigenesis in a Hep3B xenograft mouse model. (C) Photographs of tumors in representative control and Fraxini-treated mice.