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. 2019 Apr 23;9:6454. doi: 10.1038/s41598-019-42943-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model of irx2a function during segmentation and MCC specification during zebrafish nephrogenesis. (A) Renal MCC ontogeny is known to be reliant on RA signaling which acts upstream of the transcription factors mecom and etv5a, where negative regulation by Notch signaling restricts MCC fate choice. The present work adds to this model by demonstrating for the first time that irx2a functions downstream of RA signaling to regulate the expression of the etv5a transcription factor, thereby directing MCC fate. irx2a may act directly or indirectly on etv5a. irx2a likely acts on other targets as well to control MCC fate. (B) Diagram summarizing wild-type and irx2a morphant nephron segments with respect to their somite boundaries. MCC - multiciliated cell, P - podocytes, N - neck, PCT - proximal convoluted tububle, PST - proximal straight tubule, DE - distal early, DL - distal late, WT – wild-type.