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. 2019 Apr 17;13:359. doi: 10.3389/fnins.2019.00359

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Copyright © 2019 Zenz, Jačan, Reichmann, Farzi and Holzer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Poly(I:C) on locomotion (horizontal activity) (A), exploration (vertical activity, rearing) (B), water (C), and food (D) intake. Poly(I:C) (12 mg/kg) or vehicle (VEH) was injected i.p. at 0 h, and the test parameters were recorded at the subsequent time intervals shown. Values represent means + SEM, n = 6. Results of RM two-way ANOVA: F(3, 102) = 2.559, p = 0.0592 for interaction of time/treatment in locomotion; F(3, 102) = 3.400, p ≤ 0.05 for main effect of time on locomotion; F(1, 34) = 6.412, p ≤ 0.05 for main effect of i.p. treatment on locomotion; F(3, 102) = 1.992, p = 0.1199 for interaction of time/treatment in exploration; F(3, 102) = 1.855, p = 0.142 for main effect of time on exploration; F(1, 34) = 10.31, p ≤ 0.01 for main effect of i.p. treatment on exploration; F(3, 102) = 2.661, p = 0.0521 for interaction of time/treatment in water intake; F(3, 102) = 5.135, p ≤ 0.01 for main effect of time on water intake; F(1, 34) = 27.12, p ≤ 0.0001 for main effect of i.p. treatment on water intake; F(3, 102) = 3.256, p ≤ 0.05 for interaction of time/treatment in food intake; F(3, 102) = 1.730, p = 0.1656 for main effect of time on food intake; F(1, 34) = 26.87, p ≤ 0.0001 for main effect of i.p. treatment on food intake. Results of Bonferroni’s multiple comparison post hoc test: ^∗p ≤ 0.05, ^∗∗p ≤ 0.01, ^∗∗∗∗p ≤ 0.0001. Abbreviations: BW, body weight.