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. 2019 Apr 17;13:359. doi: 10.3389/fnins.2019.00359

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Copyright © 2019 Zenz, Jačan, Reichmann, Farzi and Holzer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuropeptide Y (NPY) mRNA expression is significantly upregulated in the hypothalamus of intermittently fasted mice. Mice were kept on an ad libitum feeding regimen (AL) or deprived of food on every other day (IF) for 9 days. On day 10, mice were injected i.p. with vehicle (VEH) or Poly(I:C) (12 mg/kg) and 4 h later brains were extracted to evaluate NPY mRNA expression in the hypothalamus. Values represent means ± SEM, n = 6–8. Results of two-way ANOVA: F(1, 25) = 0.2708, p = 0.6074 for interaction of feeding regimen/Poly(I:C) in NPY mRNA;F(1, 25) = 24.45, p ≤ 0.0001 for main effect of feeding regimen on NPY mRNA; F(1, 25) = 3.262, p = 0.083 for main effect of Poly(I:C) on NPY mRNA. Results of Sidak’s multiple comparison test: ^∗p ≤ 0.05, ^∗∗∗p ≤ 0.001 compared to AL/VEH.