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. 2019 Apr 23;9:6436. doi: 10.1038/s41598-019-42772-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Widespread flecks with different shapes and distributions. Group III. Patient (P) 20, P19 and P26. Blue/SW-AF(a,d,g). (a) Flecks in the macula are round and dark. Peripheral to the macula flecks are hyperAF and circularly arranged. (d) Flecks can be contiguous and hyperAF. (g) Dense small flecks were hypoAF with a few hyperAF spots scattered among and a visible hyperAF ring noted. NIR-AF (b,e,h). (b) Flecks are typically hypoAF. (e) Flecks are dark and contiguouas with central areas of atrophy. (h)The hyperAF ring in g was not detected. Green/UWF-AF (c,f,i). (c) Peripheral flecks were readily visible. (f) Branching flecks often extended into the periphery. (i) An irregular oval-shaped area of increased autofluorescence is present in green/UWF-AF image.