Fig. 2.

Multiplex communities. An emblematic example of multiplex community bridging genotypic and phenotypic information to discover new disease-disease interactions that, otherwise, would not be identified from standard analysis. In this case (Multiplex Community 15) there are no edges in common across the two layers (i.e., there is no phenotype interaction with a genetic explanation) and only two diseases are shared by the communities in the two layers, i.e. Age-related macular degeneration and acute lymphocytic leukemia, due to acute leukemia being associated with ocular comorbidity