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. 2019 Apr 23;5:15. doi: 10.1038/s41540-019-0092-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Biological process similarity of diseases. Portion of the human protein-protein interaction (PPI) network depicting the localization of disease genes and genes related to relevant biological processes. Nodes represent protein-encoding genes and edges represent literature-documented physical interactions between them. Disease genes (denoted with the dashed ellipse areas) associated with ventricular septal defect (green nodes) and DiGeorge Syndrome (cyan nodes) are connected by biological processes related to cardiac development (nodes related to outflow tract morphogenesis in blue; heart morphogenesis in red; heart development in yellow) and endocrine development (nodes related to thyroid gland development in magenta). Concentric circles around disease genes indicate overlap of disease genes with the biological process of that color