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. 2019 Apr 23;9:6456. doi: 10.1038/s41598-018-38055-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Casp1, Ifngr and Nos2 deficiency decreases anxiety-like behaviour. (a) (Casp1, Ifngr, Nos2)^−/− mice displayed increased time spent in the open arms of the elevated plus maze but (b) similar time in the centre area of the open field test. The (Casp1, Ifngr, Nos2)^−/− genotype had a main effect on (c) the number of defecations during the open field test, which was driven by the increased number of faecal boli in (Casp1, Ifngr, Nos2)^−/− mice following CUS, while this parameter remained unchanged in wt mice. Data are presented as means ± s.e.m. Genotype effect *P < 0.05; **P < 0.01; ***P < 0.001; stress effect ⁺P < 0.05; ⁺⁺P < 0.01; ⁺⁺⁺P < 0.001; genotype*stress effect ^#P < 0.05; ^##P < 0.01; ^###P < 0.001; wt = wild-type; BL = baseline; CUS = chronic unpredictable stress paradigm; wt n = 16; (Casp1, Ifngr, Nos2)^−/− n = 20.