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. 2019 Apr 23;10:1911. doi: 10.1038/s41467-019-09555-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — MYC translocations correspond with focal amplifications and aberrant expression. a Circos plot of MYC translocations in newly diagnosed myeloma (N = 795). The median VAF and frequency of each translocation is denoted by the color and thickness of the line, respectively (see keys bottom left and right). b Genome (GRCh37) plot of the MYC locus showing genes (arrows indicate the direction of transcription; 1: MIR1204, 2: TMEM75, 3: MIR1205, 4: U4, 5: MIR1206, 6: MIR1207), and the location of MYC translocations [t(MYC)]. c Frequency of copy number gains (red) and losses (blue) for all samples (solid line) and those with t(MYC) (dashed line). d A heatmap of copy number across the locus is shown for samples with either a MYC translocation (black) or only a CNA (white) sorted by the location of the MYC translocation, which are superimposed on the heatmap as 10 kb black regions. e ATAC-seq for 6 myeloma cell lines across the locus is shown below (RPM: reads per million). f Venn diagram of samples with a CNA at the MYC locus (dashed gray line), CNA boundary (solid gray line), or MYC translocation (black line). g Gene expression of MYC in samples with RNA-seq data (N = 611) for patients with no MYC alteration (none; N = 382), MYC CNA only (N = 83), MYC translocations to non-immunoglobulin genes [t(other); N = 81], IgH-MYC translocations [t(8;14); N = 27], IgK-MYC translocations [t(2;8); N = 13], and IgL-MYC translocations [t(8;22); N = 25]. ***P < 0.001, analysis of variance with Tukey’s post hoc test. Boxplots show the median and quartiles with the whiskers extending to the most extreme data point within 1.5 times the interquartile range. h Progression-free (PFS; left) and overall survival (OS; right) for patients stratified by MYC structural variant type as in part g. P-values are shown in parenthesis and were calculated using a Cox proportional hazards Wald's test and denote the significance of survival differences relative to myelomas without a detectable MYC structural variant (none). Source data are provided as a Source Data file