Fig. 7.
IgL translocated myelomas do not benefit from IMiDs. a Progression-free (PFS; left) and overall survival (OS; right) Kaplan-Meier curves for non-t(IgL) patients with (green; N = 463) or without (gray; N = 164) front-line IMiD containing therapy (PFS P = 3.3 × 10−7; OS P = 1.1 × 10−6), as well as t(IgL) patients with (blue; N = 51) and without (red; N = 23) front-line IMiD therapy (PFS P = 0.51; OS P = 0.19). b PFS (left) and OS (right) hazard ratios (HR) for the populations defined in part a. c PFS and OS as in part a except comparing non-t(IgH) patients with (green; N = 301) and without (gray; N = 111) front-line IMiD therapy (PFS P = 7.4 × 10−4; OS P = 1.7 × 10−3) as well as t(IgH) patients with (blue; N = 213) and without (red; N = 76) front-line IMiD therapy (PFS P = 1.5 × 10−4; OS P = 8.0 × 10−5). d PFS (left) and OS (right) hazard ratios (HR) for the populations defined in part c. P-values were calculated using a Cox proportional hazards Wald’s test. Hazard ratios in parts b and d were calculated relative to all other patients and 95% confidence intervals are shown. Source data are provided as a Source Data file