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. 2019 Apr 17;10:402. doi: 10.3389/fphys.2019.00402

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Copyright © 2019 Stervbo, Roch, Westhoff, Gayova, Kurchenko, Seibert and Babel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Soluble mediators are decreased after gravitational stress. (A) Single parabola with alteration in experienced gravitational acceleration. (B) Sampling scheme applied in the study – blood was taken before the first parabola (P0) and after the last (P180), both during 1 g. The day before, two samples were taken on the ground at time points of the corresponding in-flight samples (C0 and C180). (C) Principal component analysis of the change in concentration of all 51 measured molecules from t₁₈₀ to t₀. (D) Soluble mediators with significant fold change. (E–H) Soluble mediators with different time related changed between the control phase and the flight phase. The individual donors are annotated by each point for the C180/C0 ratio. (I–L) Individual samples of the data presented in panels (E–H). ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001.