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. 2019 Apr 17;10:315. doi: 10.3389/fphar.2019.00315

Figure 2.

Figure 2

Daily administration of PTZ induces chronic epilepsy in adult zebrafish. (AI) Represents the seizure progression pattern of PTZ and KA from day-1 to day-10 with F-value of 413.7, DF-18 and mean square–19.41; (AII) represents transfer latency, the time taken by PTZ and KA-treated fish against a control group. PTZ (80 mg/kg) and KA–3 mg/kg significantly increase the time taken to reach the feeding ring. The data were analyzed by GraphPad Prism v.7.02 (San Diego, CA) with repeated measure (mixed model) Two-way ANOVA followed by Bonferroni post-test to compare replicated means by row. Data are presented as means and standard errors of the mean (SEM) to assess the differences in seizure, latency, and inflexion ratio: with F-value of 22.24, DF-18 and mean square–70,622 *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001. (B) Locomotor tracking pattern of a single representative fish in a treated group with the proconvulsant drug at day-10 in three-axis maze.