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. 2019 Apr 17;10:348. doi: 10.3389/fgene.2019.00348

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Copyright © 2019 Ponsuksili, Trakooljul, Hadlich, Methling, Lalk, Murani and Wimmers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of HDAC4 by RNA interference reveals upregulation of G6PD. Two siRNAs siHDAC4_7 and siHADC4_3 were designed to target HDAC4 and transfected into human HepG2 cells in vitro. Relative mRNA expression was measured by qPCR 48 h after transfection. Expression was normalized to ß-actin internal controls. Expression of G6PD was significantly increased relative to its expression in control cells and HDAC4 levels at 48 h post-transfection of siRNA. The data represent means ± SD (n = 3).