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. 2019 Apr 17;9:289. doi: 10.3389/fonc.2019.00289

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Copyright © 2019 Hartl and Schneider.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cellular signaling pathways of the GMC proteins GAP43, MARCKS, and BASP1. The scheme summarizes the known key signaling pathways where these proteins are involved. PKC, protein kinase C; EGFR, epidermal growth factor receptor; PIP2, phosphatidylinositol-4,5-bisphosphate; PIP3, phosphatidylinositol-3,4,5-bisphosphate; GRB2, growth factor receptor bound protein 2; SOS, Ras/Rac guanine nucleotide exchange factor; ROCK, Rho associated coiled-coil containing protein kinase; RTK, receptor tyrosine kinase; IRS1, insulin receptor substrate 1; PI3K, phosphoinositide 3-kinase; PDK1, PIP3-dependent protein kinase; mTOR, mechanistic target of rapamycin kinase; MEK (MAPKK), mitogen-activated protein kinase kinase; ERK (MAPK), extracellular signal-regulated kinase; HDAC, histone deacetylase; WT1, Wilms tumor suppressor 1; PHB, prohibitin 1; CDK, cyclin-dependent protein kinase; CCN, cyclin; CDC73, cell division cycle 73; SKP2, S-phase kinase-associated protein 2. RTKs and PKC are inhibited by Regorafenib or Enzastaurin, respectively.