Table 4.
Effects of dietary daidzein supplementation of hens on DEGs used in GO clustering analysis related to the immune system.
| Gonane | GO_ID | P-value | Genes|Fold change | Count |
|---|---|---|---|---|
| Response to interleukin-8 | GO:0098758 | 6.95E-03 | EGR1|2.376 | 1 |
| Endocytosis involved in viral entry into host cell | GO:0075509 | 1.04E-02 | CAV2|0.417 | 1 |
| Cellular response to endogenous stimulus | GO:0071495 | 1.71E-05 | CAV2|0.417;ACSL1|0.614;CYR61|2.231;EGR1|2.376;JUN| 2.208;RARA|1.526;FOS|3.316;CCK1R|5.905;CHRDL1| 0.429;IRS2|1.866;KL|3.059;CRHR2|2.007;PDK4|0.421 |
13 |
| Cellular response to peptide hormone stimulus | GO:0071375 | 3.94E-04 | CAV2|0.417;IRS2|1.866;KL|3.059;CRHR2|2.007;PDK4|0.421 | 5 |
| Cellular response to chemical stimulus | GO:0070887 | 1.81E-03 | CAV2|0.417;SOD3|0.184;ACSL1|0.614;CYR61|2.231;EGR1| 2.376;JUN|2.208;PPARGC1A|0.564;RARA|1.526;FOS| 3.316;CCK1R|5.905;CHRDL1|0.429;IRS2|1.866;KL|3.059;CRHR2| 2.007;PDK4|0.421 |
15 |
| Interleukin-1-mediated signaling pathway | GO:0070498 | 4.77E-02 | EGR1|2.376 | 1 |
| Response to stimulus | GO:0050896 | 9.99E-04 | NIM1K|1.617;CAV2|0.417;CDH2|1.906;SOD3|0.184;SLC25A25| 0.627;CRCP|0.599;ACSL1|0.614;MST1R|1.705;GFRA3| 0.646;CHAC1|0.521;ENPP2|0.6;EVC|0.468;CYR61|2.231;EGR1| 2.376;JUN|2.208;PPARGC1A|0.564;TOP2A|0.53;RARA|1.526;FOS| 3.316;IGFBP1|0.446;WFDC1|0.417;GPX2|7.618;SIK1| 1.694;CCK1R|5.905;BCO1|0.596;KIAA1324|5.521;CHRDL1| 0.429;SGK2|0.559;IRS2|1.866;KL|3.059;LPAR3| 2.868;SLC6A14|0.423;CRHR2|2.007;TRPA1| 0.123;ANKRD6|0.513;EVC2|0.376;DUSP8|1.567;JAG1| 1.703;MCC|2.125;PDK4|0.421 |
40 |
| Positive regulation of response to stimulus | GO:0048584 | 3.07E-03 | CAV2|0.417;CDH2|1.906;MST1R|1.705;EVC| 0.468;CYR61|2.231;JUN|2.208;KIAA1324|5.521;KL| 3.059;LPAR3|2.868;CRHR2|2.007;ANKRD6|0.513;JAG1| 1.703 |
12 |
| Regulation of response to stimulus | GO:0048583 | 2.59E-03 | CAV2|0.417;CDH2|1.906;MST1R|1.705;CHAC1| 0.521;EVC|0.468;CYR61|2.231;EGR1| 2.376;JUN|2.208;IGFBP1|0.446;WFDC1| 0.417;KIAA1324|5.521;CHRDL1| 0.429;KL|3.059;LPAR3|2.868;CRHR2|2.007;ANKRD6| 0.513;DUSP8|1.567;JAG1|1.703;MCC|2.125 |
19 |
| Transport of virus | GO:0046794 | 3.76E-02 | CAV2|0.417 | 1 |
| Regulation of MAPK cascade | GO:0043408 | 8.82E-05 | CAV2|0.417;CDH2|1.906;MST1R|1.705;CYR61|2.231;JUN| 2.208;KL|3.059;LPAR3|2.868;ANKRD6|0.513;DUSP8|1.567 |
9 |
| Positive regulation of MAP kinase activity | GO:0043406 | 2.76E-02 | MST1R|1.705;JUN|2.208;LPAR3|2.868 | 3 |
| Regulation of MAP kinase activity | GO:0043405 | 1.10E-02 | MST1R|1.705;JUN|2.208;LPAR3|2.868;DUSP8|1.567 | 4 |
| Response to drug | GO:0042493 | 2.12E-02 | JUN|2.208;FOS|3.316;TRPA1|0.123 | 3 |
| Toll-like receptor 21 signaling pathway | GO:0035682 | 4.10E-02 | JUN|2.208 | 1 |
| Activation of MAPK activity involved in innate immune response | GO:0035419 | 4.43E-02 | JUN|2.208 | 1 |
| Cellular response to reactive oxygen species | GO:0034614 | 3.40E-02 | SOD3|0.184;FOS|3.316 | 2 |
| Cellular response to oxidative stress | GO:0034599 | 1.58E-02 | SOD3|0.184;PPARGC1A|0.564;FOS|3.316 | 3 |
| Cellular response to hormone stimulus | GO:0032870 | 2.94E-05 | CAV2|0.417;ACSL1|0.614;JUN|2.208;RARA| 1.526;CCK1R|5.905;IRS2|1.866;KL|3.059;CRHR2| 2.007;PDK4|0.421 |
9 |
| Receptor-mediated endocytosis of virus by the host cell | GO:0019065 | 1.04E-02 | CAV2|0.417 | 1 |
| Response to endogenous stimulus | GO:0009719 | 1.66E-05 | CAV2|0.417;ACSL1|0.614;CYR61|2.231;EGR1| 2.376;JUN|2.208;RARA|1.526;FOS| 3.316;CCK1R|5.905;CHRDL1|0.429;IRS2| 1.866;KL|3.059;CRHR2|2.007;JAG1| 1.703;PDK4|0.421 |
14 |
| Response to abiotic stimulus | GO:0009628 | 2.83E-02 | SOD3|0.184;EGR1|2.376;JUN|2.208;FOS|3.316;SIK1|1.694;TRPA1|0.123 | 6 |
| Response to mechanical stimulus | GO:0009612 | 6.05E-03 | JUN|2.208;FOS|3.316;TRPA1|0.123 | 3 |
| Response to external stimulus | GO:0009605 | 1.69E-03 | SLC25A25|0.627;MST1R|1.705;GFRA3|0.646;ENPP2| 0.6;JUN|2.208;PPARGC1A|0.564;FOS| 3.316;WFDC1|0.417;SIK1|1.694;KIAA1324| 5.521;CRHR2|2.007;TRPA1| 0.123;PDK4|0.421 |
13 |
| Response to oxidative stress | GO:0006979 | 2.44E-03 | SOD3|0.184;PPARGC1A|0.564;FOS|3.316;GPX2|7.618;TRPA1|0.123 | 5 |
| Antigen binding | GO:0003823 | 5.39E-05 | LOC100859408|0.197785696238; ENSGALG00000004772|0.374843424568; LOC768350|0.376374293512; ENSGALG00000027944|0.511967097185 | 4 |
| Negative regulation of B cell apoptotic process | GO:0002903 | 2.75E-02 | IRS2|1.866 | 1 |
| Response to reactive oxygen species | GO:0000302 | 8.32E-03 | SOD3|0.184;FOS|3.316;TRPA1|0.123 | 3 |