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. 2019 Apr 23;9:6354. doi: 10.1038/s41598-019-42936-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AS-1 attenuates Ang II-induced cardiac hypertrophy in vivo. Mice were continuously administrated with either Ang II or normal saline using a mini-pump for 28 days. 3 days before which, mice were intraperitoneally injected with AS-1. Hearts were harvested and weighted. (A) The ratio of HW/BW among each group was calculated and compared. (B) The ratio of LVW/TL among each group was calculated and compared. (C) Representative images of WGA staining on paraffin-embedded heart sections from each group. sham: mice treated with saline. Ang II: mice treated with Ang II. Ang II + DMSO: mice induced by Ang II and i.p. injected with DMSO. Ang II + AS-1: mice induced by Ang II and i.p. injected with AS-1. Mean ± SEM, n = 6, *p < 0.05, **p < 0.01, ***p < 0.001.