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. 2019 Apr 23;9:6424. doi: 10.1038/s41598-019-42377-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mouse model of gestational exposure to Mixture S. Pregnant mice were exposed throughout pregnancy to vehicle or to 10x, 100x and 500x the geometric mean of SELMA study mothers’ urine/serum levels for the phthalate monoesters in Mixture S. Offspring’s anogenital index and sex ratio was monitored on postnatal day (PND) 1. A split- sex and litter design was used to study the effects of Mixture S on the reproductive system of the offspring at pre-puberty (PND21) and adulthood (PND90). Outcomes analyzed include AGD index, gonadal histology, expression of key gametogenesis and steroidogenesis regulators and circulating hormone levels.