Table 2.
Reproductive indices of male and female offspring.
| AGD/cubic root of BW | DMSO | 10x | 100x | 500x |
|---|---|---|---|---|
| Males | ||||
| PND1 | 1.41 ± 0.02 (34) |
1.52 ± 0.04 (14) |
1.42 ± 0.03 (19) |
1.37 ± 0.03 (26) |
| PND21 | 3.81 ± 0.04 (30) |
3.61 ± 0.07* (13) |
3.56 ± 0.05¤ (19) |
3.79 ± 0.04 (26) |
| PND90 | 6.42 ± 0.05 (21) |
6.16 ± 0.08* (8) |
6.43 ± 0.07 (12) |
6.41 ± 0.06 (13) |
| Females | ||||
| PND1 | 0.93 ± 0.02 (26) |
1.06 ± 0.03# (15) |
0.98 ± 0.02 (14) |
0.94 ± 0.02 (16) |
| PND21 | 2.29 ± 0.03 (24) |
2.13 ± 0.04¤ (17) |
2.01 ± 0.04# (14) |
2.27 ± 0.04 (12) |
| PND90 | 3.26 ± 0.03 (14) |
3.18 ± 0.04 (9) |
3.24 ± 0.04 (9) |
3.24 ± 0.04 (9) |
| Gonad weight/BW | DMSO | 10x | 100x | 500x |
| Males | ||||
| PND21 | 3.05 ± 0.04 (11) |
3.21 ± 0.06 (5) |
2.85 ± 0.06* (7) |
2.90 ± 0.05 (9) |
| PND90 | 4.41 ± 0.06 (21) |
4.35 ± 0.09 (7) |
4.28 ± 0.07 (12) |
4.28 ± 0.07 (10) |
| Females | ||||
| PND21 | 0.90 ± 0.29 (10) |
0.87 ± 0.03 (8) |
0.65 ± 0.04# (5) |
0.84 ± 0.04 (5) |
| PND90 | 1.18 ± 0.056 (14) |
0.89 ± 0.07 (9) |
0.78 ± 0.07# (9) |
1.15 ± 0.06 (9) |
AGD/cubic root of BW and gonad weight/BW values for postnatal day (PND) 1, 21 and 90 male and female offspring exposed to DMSO or to 10x, 100x and 500x of SELMA mothers’ levels for the chemicals in Mixture S. In the statistics of gonad weight/bw, the phase of the estrous cycle of PND90 females was included as covariate. Values represent estimated marginal means ± SE. The number of animals is given in parentheses. *p < 0.05; ¤p < 0.01; #p < 0.001 vs. DMSO.