Fig. 3.

Release of DHA and OxPt from OxPt/DHA. a Proposed DHA release via GSH-mediated disulphide cleavage and proton-catalysed hydrolysis. b Proposed release of OxPt via direct reduction by ascorbate or a two-step sequence of hydrolysis to generate OxPt-bc followed by reduction to OxPt. c Total Pt release from and chol-DHA remaining in OxPt/DHA particle when incubated in water at 37 °C with or without 0.5% Triton X-100 and 5 mM ascorbate. The data were obtained without repetition. OxPt oxaliplatin, DHA dihydroartemisinin, GSH glutathione