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. 2019 Apr 23;9:6370. doi: 10.1038/s41598-019-42783-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Retention of erythropoietin (a), low molecular weight heparin (LMWH) (b), insulin (c) and vancomycin (d) in a simulated treatment with medium cut-off (MCO) and high-flux dialysers. Data are presented as mean (n = 3) ± standard error of the mean (SEM). Insulin concentrations at t0 were out of the range of the insulin assay (>1 IU/L). No consistent starting concentrations could be achieved, and the starting concentration of 1 lU/L was chosen to be high enough so that insulin would still be detectable over the time frame of the experiments. HD, haemodialysis; HDF, haemodiafiltration; PES, polyethersulfone; PSu, polysulfone.