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. 2019 Apr 23;10:1914. doi: 10.1038/s41467-019-09839-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — BNTA attenuated post-traumatic osteoarthritis development after intra-articular injection for 4 and 8 w. a, b Representative images of safranin O-fast green, alcian blue, immunohistochemistry staining of type II collagen (COLII), and the corresponding Osteoarthritis Research Society International (OARSI) scores from normal, sham, veh (vehicle)-treated, and BNTA-treated rats at 4 w (n = 8 for each group; nonparametric test; M, meniscus; F, femur; T, tibia; safranin O-fast green staining, scale bar, 200 μm; alcian blue and immunohistochemistry staining, scale bar, 100 μm). c, d Representative images of safranin O-fast green, alcian blue, immunohistochemistry staining of COLII, and OARSI scores in normal, sham, vehicle, and BNTA rats at 8 w (n = 8 for each group; nonparametric test; safranin O-fast green staining, scale bar, 200 μm; alcian blue and immunohistochemistry staining, scale bar, 100 μm). e Pain response times when rats were placed on the 55 °C hot plate meter at 4 w and 8 w post-surgery (n = 8 for each group, one-way ANOVA). f The difference between the weight placed on the contralateral sham (left) hindlimb and the weight placed on the anterior cruciate ligament transection (ACLT, right) one at 4 w and 8 w post-surgery (n = 8 for each group, one-way ANOVA). Each data point represents one individual rat. All data are shown as the mean ± standard deviation (s. d.). *P < 0.05, **P < 0.01, ***P < 0.001. Source data are provided as a Source Data file