Fig. 6.

BCL2 variant predict response to paclitaxel in 39 ovarian cancer cell lines. a Histogram showing the response of 39 different ovarian cancer cell lines to paclitaxel with their BCL2 variant status (cell lines with wild-type BCL2 marked in gray, heterozygous BCL2 marked in light blue and homozygous for the variant marked in dark blue). Cell lines with low AUC (sensitive to paclitaxel) are enriched with wild-type BCL2, while cells with high AUC (resistant) are enriched with the variant form. b–d This phenomenon is to observed in other cytotoxic treatment such as vincristine, topotecan, and doxorubicin. e This was tested across 406 different treatments, and the only response paclitaxel was the only significant association with the presence of the variant