Figure 8.

Structure of the experiment. Male C57BL/6 mice were submitted to subcutaneously infection by S. mansoni (40 cercariae). After 16 weeks of infection, the animals were submitted to the conventional chemotherapy with praziquantel (400 mg/Kg) (B, C e D groups). Cell therapy was initiated after 18 weeks of infection with 10⁶ bone marrow mononuclear cells (C) or 10⁶ monocytes (D). Group B received only saline (vehicle). Healthy uninfected mice were used as control (Group A). The therapeutic procedure was performed once a week for three consecutive weeks. Eight weeks after cell therapy (26^th week), the animals were submitted to euthanasia for liver collection (6 mice/group). The study data are a mean calculated from two independent experiments.