Table 1.
Subject demographic and clinical annotation in the discovery and validation cohorts
| Variable | Discovery cohort (n = 30) | Validation cohort (n = 20) | P value |
|---|---|---|---|
| Average # biopsies/subject | 6.6 (5.7) | 5.25 (2.9) | 0.3 |
| Average # bronchoscopies/subject | 3.1 (1.6) | 2.5 (0.7) | 0.08 |
| Average time between bronchoscopies (days) | 348.6 (197.5) | 366.8 (208.3) | 0.69 |
| Male | 15/30 (50) | 12/20 (60) | 0.81 |
| White | 27/30 (90) | 17/20 (85) | 1 |
| Age (at baseline clinical visit) | 58.8 (7.6) | 58.7 (8.3) | 0.97 |
| Ever smoker (at baseline clinical visit) | 29/30 (96.7) | 19/20 (95) | 1 |
| Pack-years (at baseline clinical visit) | 49.8 (22.1) | 41.3 (20.7) | 0.17 |
| Prior history of lung cancer | 21/30 (70) | 12/20 (60) | 0.82 |
| Prior history of LUSC | 5/30 (16.7) | 5/20 (25) | 0.73 |
| COPD (FEV1/FVC ≤ 0.7, at baseline clinical visit) | 17/27 (63.0) | 8/18 (44.4) | 0.61 |
| GOLD 1 (FEV1%> 80) | 2/27 (7.4) | 2/18 (11.1) | 1 |
| GOLD 2 (FEV1% < 80 and > 50) | 12/27 (44.4) | 5/18 (27.8) | 0.56 |
| GOLD 3 (FEV1% < 50 and > 30) | 3/27 (11.1) | 1/18 (5.6) | 1 |
| Occupational asbestos | 13/30 (43.3) | 9/20 (45) | 1 |
| Occupational high-risk job | 14/30 (46.7) | 12/20 (60) | 0.62 |
Statistical tests between the discovery and validation cohorts were performed using two-sided Fisher’s exact tests for categorical variables and two-sided Student’s t-tests for continuous variables. Percentages are reported for categorical variables and mean and standard deviations are reported for continuous variables. Source data are provided as a Source Data file