Table 1.
Baseline Characteristics of the Three HCV Infected Hemodialysis Patients who Previously Failed to Respond to Daclatasvir and Asunaprevir.
| Case 1 | Case 2 | Case3 | ||||
|---|---|---|---|---|---|---|
| Age (years) | 57 | 69 | 68 | |||
| Sex | Female | Female | Female | |||
| Baseline white blood cell count (/μL) | 5,730 | 2,500 | 2,500 | |||
| Baseline hemoglobin level (g/dL) | 17.5 | 13.6 | 14.2 | |||
| Baseline platelet count (×103/μL) | 127 | 111 | 87 | |||
| Baseline ALT level (IU/L) | 15 | 7 | 10 | |||
| Baseline AST level (IU/L) | 14 | 14 | 12 | |||
| Baseline HCV RNA level (log10 IU/mL) | 5.2 | 6.9 | 4.2 | |||
| HCV genotype | 2b | 1b | 1b | |||
| FIB-4 index | 1.6 | 3.3 | 3.0 | |||
| IL28 B gene (rs8099917) | TG | TT | TT | |||
| Previous treatment | DCV/ASV | DCV/ASV | DCV/ASV | |||
| Response to previous treatment | Non-response | Viral breakthrough | Relapse | |||
| Etiology of renal dysfunction | DM | DM | Nephrosclerosis | |||
| HD duration (years) | 23 | 13 | 14 | |||
| NS5A RAVs | NA | R30Q, L31M, Y93H | L31M, Y93H | |||
| NS3 RAVs | NA | none | D168E |
HCV: hepatitis C virus, IFN: interferon, ALT: alanine transaminase, DCV: daclatasvir, ASV: asunaprevir, RAVs: resistance associated variants, ART: antiretroviral therapy, Tx: treatment, ND: not detected, NA: not analyzed