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. 2019 Apr 23;87(5):e00126-19. doi: 10.1128/IAI.00126-19

FIG 3.

FIG 3

T cells protect against systemic challenge with Pla-deficient Y. pestis in a fibrin-dependent manner. WT (A to C), FibKO and FibHet (D), or mTFKO, mTFHet, and P/T DKO (E) mice were immunized intranasally with CT, CT+YopE, or CT+OVA and then challenged intravenously with 10 MLD strain CO92 (A), strain CO92 ΔPla (B), or strain CO92 Pla-D206A (C to E). YopE immunization provides fibrin-sufficient mice with significant protection against systemic infection with Pla-deficient Y. pestis. Data for all panels are pooled from 2 to 3 independent experiments (ns, not significant).