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. 2019 Apr 23;87(5):e00126-19. doi: 10.1128/IAI.00126-19

FIG 4.

FIG 4

T cell-mediated protection against plague displays an inverse relationship with Y. pestis Pla activity. (A) Plasminogen-activating capacity of indicated Y. pestis strains measured in vitro using a chromogenic assay for plasmin and presented as the absorbance at 405 nm at the indicated time points. Data are representative of results from 2 independent experiments. (B) WT mice were immunized intranasally with CT or CT+YopE and challenged intranasally with 20 MLD strain CO92 pgm−. In comparison with control mice, YopE-immunized mice exhibited significantly increased survival after CO92 pgm− challenge. Data shown are pooled from 3 independent experiments. (C) Inverse relationship between Pla activity and the survival rate of YopE-immunized WT mice challenged intranasally with 10 to 20 MLD of the indicated Y. pestis strains. Survival data were pooled from 2 to 3 independent experiments. Pla activity data are representative of results from 2 independent experiments and are presented as the OD value measured at 50 min.