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The ClpXP protease contributes to S. aureus skin infection under diabetic conditions. Diabetes was induced in mice using streptozotocin (STZ). (A) Mice were subcutaneously infected with 2 × 106 CFU of S. aureus USA300, and the area of dermonecrosis was monitored over time. (B) Bacterial quantification from punch biopsy specimens (n = 8). Data are from two independent experiments. ***, P < 0.001.
