FIG 3.
IL-10 production modulates lung damage during KP35 infection. WT and IL-10−/− mice were intranasally infected with 1 × 108 CFU of KP35, and different parameters of lung damage were evaluated, including lung histopathology by H&E staining (A), lung histopathological score (B), total BALF proteins (C) and total lung cell apoptosis by TUNEL assay (D) and TUNEL-positive area (E). (F) Neutrophil activation was measured by the quantification of MPO activity in the BALF. Scale bar, 2 mm. *, P < 0.05, for a comparison of results between groups at each time point or between the infected group and the respective uninfected (Unf) group (two-way ANOVA with a Tukey posttest).