FIG 1.

C. neoformans sequence types and human mortality. C. neoformans clinical strains were isolated from the CSF of HIV-infected patients with CM, grown on YPD agar medium at 30°C, and stored at −80°C before their sequence types were identified. (A) Cryptococcus strains from all participants have different sequence types and can be classified as early- versus late-mortality strains. (B) To test the association between human and mouse infections, 11 strains with various sequence types and different degrees of human mortality were chosen to be tested in the mouse model of cryptococcosis. The sequence type and human mortality for this subset of strains are presented. Early mortality indicates that the patient died within 10 weeks from the time of diagnosis, late mortality indicates that the patient died after 10 weeks, and survival indicates that the patient survived the infection. Unique ST, sequence types infecting only one patient.