FIG 5.

Disease outcome in humans is associated with disease outcome in mice. The clinical outcome in human participants was compared to the infection outcome in mice infected with the same C. neoformans strain. (A) Correlation between human and mouse survival for all 10 clinical strains. (B) Correlation between human and mouse survival when outliers (the SACl010 and UgCl552 strains) were removed. *, the SACl010 strain was associated with low virulence in mice, but the human participant died of IRIS at 41 days postdiagnosis; #, the participant infected with UgCl552 died at home after clearing the initial C. neoformans infection. The cause of death was not determined.