Fig. 4.

Genome-wide targeting of BRD9 directly regulates gene expressions. a The genomic distribution of BRD9 binding sites in G401 cells. b Venn diagram of overlap between SMARCA4 and BRD9 peaks and definition of the three classes of BRD9 peaks. c The average ChIP enrichment profile of BRD9, SMARCA4, SMARCC1, H3K27Ac, and H3K4me3 over class I, class II, and class III peak regions (top). Heatmap illustrating the ChIP-seq signal 5 kb up- and downstream of the different peak classes. The genomic distribution of each class is shown in the right. d Examples of BRD9, SMARCA4, SMARCC1, H3K27Ac, and H3K4me3 ChIP-seq at representative Class I, II, and III peak regions. e Comparison of motif enrichment in different peak regions. Size of the circle represents the significance of the motif