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. 2019 Apr 23;10:1906. doi: 10.1038/s41467-019-09930-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Overall study pipeline. a Schematic representation of antibody structure and the process of VDJ recombination responsible for the diversity produced in the immune repertoire. b B-cell clone defined as cells from a common ancestor and c analytical pipeline of the study: B-cell sequencing for gDNA and cDNA, diversity analysis considering the number of clones (richness) and the frequency of each clone (Shannon entropy), network analysis and clonal and IGHV gene analysis