Table 1.
Subjects characteristics included in the study
| Total | NP | PNR | PR | P-value | ||
|---|---|---|---|---|---|---|
| Total subjects | 27 | 10 | 10 | 7 | ||
| Age donor | Mean [min–max] | 30 [15–47] | 26 [15–47] | 33 [17–44] | 31 [20–42] | 0.2 |
| Age recipient | Mean [min–max] | 12 [1–19] | 13 [8–19] | 10 [3–19] | 11 [1–17] | 0.3 |
| Gender donor | Male/female | 14/13 | 7/3 | 5/5 | 2/5 | 0.2 |
| Gender recipient | Male/female | 16/11 | 5/5 | 6/4 | 5/2 | 0.7 |
| Donor source | Cadaver | 13 | 6 | 4 | 3 | |
| Living/related | 14 | 4 | 6 | 4 | 0.6 | |
| Race recipient | Caucasian | 12 | 2 | 6 | 4 | |
| AA | 6 | 4 | 1 | 1 | 0.2 | |
| Asian | 1 | 0 | 0 | 1 | ||
| Other | 8 | 4 | 3 | 1 | ||
| Immunosuppression | Steroid-based | 13 | 6 | 4 | 3 | |
| Steroid-free | 14 | 4 | 6 | 4 | 0.6 | |
| HLA mismatch | Mean [min–max] | 4 [1–6] | 4 [3–6] | 4 [1–6] | 4 [2–6] | 0.8 |
| Cause of ESRD | Non-immune structural mediated | 4 | 2 | 2 | 0 | 0.6 |
| Other/unknown | 13 | 5 | 5 | 3 | ||
| Reflux | 10 | 3 | 3 | 4 | ||
| Rejection time (months) | Mean [min–max] | 12.5 [6.0, 24.0] | ||||
| DSA | 2 | 0 | 1 | 1 | - |
There were no significant differences for any of the donor and recipient characteristics by clinical outcome, including HLA mismatch and end-stage renal disease (ESRD) that was classified in three main groups: Non-immune structural mediated (polycystic kidney disease and aplastic/hypoplastic/dysplastic kidneys), Reflux (obstructive uropathy, pyelonephritis/interstitial nephritis and reflux nephropathy) and other/unknown (focal segmental glomerulosclerosis, cystinosis, hemolytic uremic syndrome, cortical necrosis, other and unknown). Class I DSA was developed in one individual in the PNR and also was found at time 0 in another individual in the PR group