Table 1. Summary of fertility in adult men following treatment with various gonadotoxic drugs.

Group	Definite gonadotoxicity	Diagnosis	Effect on spermatogenesis
Alkylating agents	Cyclophosphamide, busulfan, chlorambucil, procarbazine, etc.	HL, NHL, GCT, sarcomas	May induce azoospermia within 90 days
Platinum-based agents	Cisplatin, carboplatin	HL, NHL, GCT, bladder cancer	Spermatogenesis affected, possible chromosomal aberrations
Vinca alkaloids	Vincristine, vinblastine	HL, NHL, leukemia	Spermatogenesis arrested, spermatozoa motility reduced
Antimetabolites	Cytarabine	HL, NHL, leukemia, bladder cancer, colorectal cancer	Spermatogenesis affected, possible chromosomal aberrations
Topoisomerase inhibitors	Etoposide, doxorubicin	HL, NHL, GCT, sarcomas	Cytotoxic with possible chromosomal anomalies

HL: Hodgkin lymphoma, NHL: non-Hodgkin lymphoma, GCT: germ cell tumor.

Adapted from Howell and Shalet (J Natl Cancer Inst Monogr 2005;(34):12-7) [16], and Osterberg et al (Urol Ann 2014;6:13-7) [38].