Table 3.
Ring survival rates (RSA0–3h) of parasite isolates stratified by the K13 alleles.
| Mutations | n | Median RSA (%) | IQR | P* |
|---|---|---|---|---|
| WT# | 48 | 2.5 | 1.0–4.9 | – |
| K189T | 2 | 8.9 | 7.5–10.4 | 0.1403a |
| E252Q | 2 | 5.2 | 3.0–7.4 | 0.451a |
| P441L | 1 | 0.5 | – | 0.0003b |
| F446I | 55 | 5.2 | 3.1–8.2 | 0.002a |
| N458Y | 1 | 7.5 | – | 0.0003b |
| G533S | 15 | 4.6 | 3.3–7.1 | 0.0193a |
| R539T | 1 | 15.3 | – | 0.0003b |
| P574L | 3 | 1.6 | 1.3–11.7 | 0.921a |
| C580Y | 1 | 0.0 | – | 0.0003b |
| A676D | 2 | 16.7 | 15.6–17.7 | 0.0061a |
| H719N | 3 | 5.4 | 1.3–8.8 | 0.4571a |
*Comparison between the isolates carrying individual K13 mutations with the WT. P values shown here are after Benjamini-Hochberg corrections.
#Parasite isolates without any point mutations (including 28 parasites with the NN insertion).
a
Mann-Whitney U test.
b
Wilcoxon matched-pairs signed-rank test.