Table I.

Literature data report on HS and amyloidosis

Study	Age of patient (y)	HS duration (y)	Previous therapies	Comorbidities	Localization	Clinical amyloidosis presentation	Detection of amyloid deposits	Assigned therapy	Outcome
Titze et al2	62	25	NR	Coronary heart disease, hypertension, hypercholesterolemia	Axillae, inguinal areas, perineal area	Nephrotic syndrome, diarrhea	Colon biopsy	Ramipril, diuretics, cefuroxime	Kidney failure
Caliskan et al3	44	NR	None	None	Axillae, inguinal areas, perianal area	Nephrotic proteinuria	Kidney biopsy	Ramipril, colchicine	Kidney failure
Montes-Romero et al4	39	9	Antiandrogens, topic and systemic antibiotics, isotretinoin	Hypothyroidism	Axillae, perineal area, scrotum, Perianal area	Nephrotic proteinuria	Kidney biopsy	Infliximab	Improvement in 14 wks
Girouard et al5	39	21	Infliximab, surgery Systemic tetracycline, linezolid and clindamycin	NR	NR	Nephrotic proteinuria	Kidney biopsy	Adalimumab and fludrocortisone	Improvement
Ilgen et al6	42	3	Topical steroids, topical keratolytics, systemic roxithromycin, rifampicin and clindamycin	None	Axillae, inguinal areas, perineal area, perianal area	Nephrotic syndrome	Perineal skin biopsy Kidney biopsy	Colchicine	Kidney failure
Utrera-Busquets et al7	37	16	Systemic antibiotics, antiandrogens, dapsone, prednisone, infliximab, methotrexate, adalimumab	Graves disease, obesity	Axillae, inguinal areas, gluteal area	Nephrotic syndrome	Renal biopsy	Allopurinol, furosemide, sodium bicarbonate, lanthanum carbonate, systemic prednisone and clindamycin, surgery	Improvement in 24 wks
Schandorff et al8	54	8	Long-term systemic tetracycline, systemic rifampicin and clindamycin	None	Anogenital region, inguinal areas	Kidney failure	Renal biopsy	Acitretin, prednisolone, adalimumab, anakinra, surgery	Kidney failure
Özer et al9	43	11	Systemic antibiotics and steroid injections	None	Axillae, inguinal areas	Nephrotic proteinuria	Renal biopsy	Infliximab	Improved in 4 wks

NR, Data not reported.