Table 2.

Hypothalamic–pituitary endocrine deficiencies at last visit in childhood-onset craniopharyngioma patients (n), recruited with primary presurgical involvement of anterior + posterior hypothalamus in KRANIOPHARYNGEOM 2007, with regard to surgical hypothalamic lesions (HL), graded as previously described (17, 18) and irradiation (XRT).

	Total cohort		No HL		Ant HL		Ant + post HL		P
	No XRT	XRT	No XRT	XRT	No XRT	XRT	No XRT	XRT	No XRT	XRT
Diabetes insipidus centralis, n	43	35	3	8	11	13	29	14	0.068	0.030
Growth hormone deficiency, n	33	27	5	9	8	8	20	10	1.0	1.0
Hypothyroidism, n	41	39	5	12	8	13	28	14	0.645	0.701
Hypocortisolism, n	40	35	3	11	8	11	29	13	0.085	0.734
Hypogonadism, n	15	17	2	6	3	6	10	5	0.886	0.829

The P values refer to comparisons between the hypothalamic lesion subgroups within the context of whether or not the patient received XRT.

ant, anterior; HL, hypothalmic surgical lesion; post, posterior.