Figure 3.

Roles for UPR molecules in T cells. UPR associated proteins play important roles at all stages in the life of a T cell. Proteins in black appear to play a direct role in T cells, while proteins in red promote effector functions when the T cell is placed in a less than optimal environment (i.e., reduced glucose metabolism, amino acid deprivation, oxidizing environment, etc.). Proteins with a question mark may play a role, but further studies need to be embarked upon.