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Amino acid substitution susceptibility to disease-causing or neutral variants within protein interfaces. The bars show the percentage of residues of a given type that are found mutated in disease-causing variants (in blue) or neutral variants (in red). Asterisks show statistical significance according to a “N-1” χ2 test (* 0.01 < p < 0.05; ** 0.001 < p < 0.01).
