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. 2019 Apr 2;24(7):1279. doi: 10.3390/molecules24071279

Figure 2.

Figure 2

Figure 2

Effect of NQ 4 on the viral titer reduction of HHV-1, HHV-2 and DENV-2 in simultaneous and post-infection treatments. Vero or BHK-21 cells were infected with HHV-1 (a), HHV-2 (b) and DENV-2 (c) and treated with several concentrations of NQ 4 at different stages of the viral replicative cycle. Virions were quantified by plaque forming unit (PFU) titration (PFU/mL). Bars represent the mean ± SEM relative to DMSO control from two independent experiments. p values were determined by unpaired Student’s T-test (***, p < 0.001; **, p < 0.01). DMSO: dimethyl sulfoxide; DS: dextran sulfate (5 µg/mL); A: acyclovir, (1.5 µg/mL); H: heparin (10 µg/mL); R: ribavirin (3.7 µg/mL); NQ 4 against HHV serotypes (0.4–3.1 µg/mL); NQ 4 against DENV-2 (0.4–1.6 µg/mL).