Table 2.
Reduction of viral titer and antiviral activity against Human Herpesvirus type 1 (HHV-1) and 2 (HHV-2) on infected Vero cells of selected 1,4-naphthoquinones (NQ) and 1,4-anthraquinones (AQ).
| Type | Compound | HHV-1 | HHV-2 | ||
|---|---|---|---|---|---|
| Rf c | 1 TCID50 a (µg/mL) d | Rf c | 10 TCID50 b (µg/mL) d | ||
| NQ | 2 | 102 | 6.25 | 101 | 25 |
| 3 | nd | >50 | 102 | 6.25 | |
| 4 | 102 | 6.25 | 102 | 12.5 | |
| 6 | 102 | 6.25 | nd | >50 | |
| 7 | 101 | 50 | nd | >50 | |
| 8 | 102 | 25 | nd | >50 | |
| AQ | 10 | 102 | 6.25 | nd | >50 |
| 12 | nd | >50 | 102 | 25 | |
| 13 | nd | >50 | 101 | 12.5 | |
| 15 | 101 | 50 | nd | >50 | |
| 16 | 101 | 50 | nd | >50 | |
| 17 | 101 | 50 | nd | >50 | |
| 18 | 101 | 25 | nd | >50 | |
| DS | 102 | 0.5 | nd | ||
| A | 104 | 1.5 | 104 | 1.5 | |
a 1 TCID50: 1 Cell Culture Infectious Dose 50%; b 10 TCID50: 10 Cell Culture Infectious Dose 50%; c Rf: Reduction factor of the viral titer; d Non-toxic concentration that showed viral reduction factor; nd: Not determined; DS: Dextran sulfate; A: Acyclovir. The most potent compound is bolded for better comparison.