Figure 1.

Conceptual diagram of “polyclonal” synthetic HCP-binding resins. Targeted HCP capture is not only possible, but standard practice for HCP quantification using HCP ELISA via polyclonal α-HCP antibodies, as depicted on the left. We propose the generation of a set of diverse ligands to mimic the broad capture of varied HCP species with low binding of IgG, as shown on the right, to allow for targeted capture without the expense and variability introduced by antibody-based ligands.