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. 2019 Apr 3;20(7):1664. doi: 10.3390/ijms20071664

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Alzheimer’s disease neuropathology in humans. (A) Senile plaques and globose diffuse deposits demonstrated with anti-Aβ antibody (M 0804, Dako). (B) Neurofibrillary tangles demonstrated by phosphorylated tau protein immunohistochemistry (PHF-tau; AT8, Thermo Scientific). Reprinted from Journal of Alzheimer’s disease, 53, Taipa R., Melo-Pires M., Sousa L., Sousa N.: Does the Interplay Between Aging and Neuroinflammation Modulate Alzheimer’s Disease Clinical Phenotypes? A Clinico-Pathological Perspective, 403–417, 2016, with permission from IOS Press [59].