Table 2.
Weighted* cross-sectional associations of plasma metabolites with lacunar infarcts, Atherosclerosis Risk in Communities (ARIC) Study, 2011 to 2013. Odds ratios and 95% confidence intervals (CI) per 1-standard deviation difference in the log-transformed phospholipid.
| Brain MRI | Metabolites | Model | n | Odds ratio (95% CI) | p-value |
|---|---|---|---|---|---|
| Lacunar infarct (n = 54) | PC aa C36:5 | Model 1 | 238 | 1.13 (0.74, 1.72) | 0.58 |
| Model 2 | 238 | 1.69 (1.01, 2.83) | 0.04 | ||
| PC aa C36:6 | Model 1 | 238 | 1.16 (0.76, 1.76) | 0.49 | |
| Model 2 | 238 | 1.48 (0.85, 2.58) | 0.17 | ||
| SM C26:0 | Model 1 | 238 | 1.03 (0.72, 1.46) | 0.88 | |
| Model 2 | 238 | 0.94 (0.52, 1.69) | 0.84 | ||
| SM (OH) C22:1 | Model 1 | 238 | 1.03 (0.67, 1.60) | 0.88 | |
| Model 2 | 238 | 0.85 (0.41, 1.74) | 0.65 | ||
| SM (OH) C22:2 | Model 1 | 238 | 0.98 (0.61, 1.57) | 0.93 | |
| Model 2 | 238 | 1.03 (0.52, 2.04) | 0.94 | ||
| SM (OH) C24:1 | Model 1 | 238 | 0.95 (0.65, 1.40) | 0.80 | |
| Model 2 | 238 | 0.74 (0.38, 1.46) | 0.39 | ||
| Model 1: Logistic regression adjusted for age, race/center, sex, APOE, and education level | |||||
| Model 2: Model 1 with additional adjustment for body mass index, diabetes mellitus, drinking status, HDL cholesterol, smoking status, sports index, systolic blood pressure, total cholesterol, triglycerides, use of antihypertensive medications (yes or no), use of statins (yes or no), depression, and prevalence of coronary heart disease, heart failure, and stroke at the ARIC visit 5. | |||||
*All analyses incorporated a weight accounting for selection into the metabolite study group from the ARIC visit 5 sample. Bold type indicates p value less than 0.05. MRI: Magnetic resonance imaging; WMH: White matter hyperintensity.