Table 5.
Warfarin Cohort Bleeding Events, Thromboembolism, Hospitalization, and Mortality Eventsa
| Case No. | Bleed(s) (Severitya) | Thromboembolism | Hospitalization Event(s) | Bleed or Thromboembolism event during stabilization period? (Y/N) | AchievedTarget Dose Within Pharmacogenetics Alert Recommendaiton? (Y/N) | Patient Initiated on Warfarin Dose Within Pharmacogenetics Alert Recommendation? (Y/N) | Initial Warfarin Dose (mg/day) | Stable Warfarin Dose(mg/day) |
|---|---|---|---|---|---|---|---|---|
| 1 | 2 (1 minor, 1 moderate) | 0 | 0 | N | N | Y | 2 | 3.3 |
| 3 | 1 (moderate) | 0 | 2 | N | Y | Y | 5 | 5.36 |
| 7b | 2 (minor) | 1c | 5d | Y | Y | N | 3e | 6 |
| 8 | 1 (minor) | 0 | 0 | N | Y | N | 5e | 2.5 |
| 9 | 1 (minor) | 0 | 1 | Y | Y | N | 2e | 5.14 |
a Severity definitions: minor bleed = bleed requiring home care; moderate bleed = bleed requiring doctor visit; major bleed = bleed requiring hospitalization or blood product transfusion.
bDeath may have been related/impacted by a possible thromboembolic event; however, death was likely multifactorial, see patient case description.
c“Possible strokes with right hemi-paresis” noted in EMR.
dOne of the 5 hospitalization events may have been related to a possible thromboembolic event (“Possible strokes with right hemi-paresis” noted in EMR).
ePatient initiated on warfarin dose outside of PGx alert recommendation.