Figure 3.
Effect of inhibition of AQP3 function on permeability to various drugs. Caco-2 cells were plated in Transwell plates and incubated for 21 days. (A) Antipyrine alone or a combination of antipyrine and HgCl2 was added to the apical side of the Transwell plate. The concentration of antipyrine on the basal side was measured. (B) Atenolol alone or a combination of atenolol and HgCl2 was added to the apical side of the Transwell plate. Furosemide alone or a combination of furosemide and HgCl2 was added to the apical side of the Transwell plate. At 120 min after addition, the concentration of atenolol or furosemide on the apical side was measured. The data are presented as the mean ± SD for six experiments.