Table 2.
The genomic segments significantly over-expressed in the total normal thyroid (Pool A) vs. histologically normal thyroid adjacent to papillary thyroid carcinoma (Pool B) differential transcriptome map. Over-expressed genes are in bold, under-expressed genes are with an asterisk and in bold. Under-expressed genomic segments were not found.
| Chr and location | Segment start | Segment end | Value A/B | q-value | Genes in the segment |
|---|---|---|---|---|---|
| chr4 (4q13.3) | 70,000,001 | 70,500,000 | 105.52 | 0.00000017 | STATH HTN3 HTN1 MR3A SMR3B MUC7 |
| chr4 (4q13.3) | 70,250,001 | 70,750,000 | 21.34 | 0.00201816 | SMR3A SMR3B MUC7 UTP3* |
| chr12 (12p13.2) | 11,000,001 | 11,500,000 | 9.31 | 0.00214630 | PRH1 PRB3 PRB4 |
| chr20 (20p11.21) | 23,500,001 | 24,000,000 | 6.99 | 0.00000413 | CST3 CST4 CST1 CST2 CST5 |
| chr12 (12p13.2) | 10,750,001 | 11,250,000 | 6.05 | 0.00335694 | TAS2R10 PRR4 PRH1 |
| chr16 (16q23.1-q23.2) | 78,500,001 | 79,000,000 | 4.50 | 0.00024953 | Hs.649237 Hs.648714 Hs.649874 |
| chr17 (17q21.2) | 41,250,001 | 41,750,000 | 3.61 | 0.00021980 | KRT31 KRT35 KRT13 KRT15 KRT14 |
| chr1 (1q21.3) | 152,250,001 | 152,750,000 | 3.44 | 0.00113717 | CRNN CRCT1 LCE2B |
| chr1 (1q21.3) | 153,000,001 | 153,500,000 | 3.15 | 0.00004193 | SPRR3 SPRR1B PGLYRP3 S100A9 S100A12 |
| chrX (Xq13.2) | 74,000,001 | 74,500,000 | 2.88 | 0.00011566 | Hs.720466 FTX Hs.607917 Hs.625698 |
| chr17 (17q21.2) | 41,000,001 | 41,500,000 | 2.51 | 0.00003900 | KRTAP1-5 KRTAP4-6 KRTAP4-4 KRTAP4-1 KRTAP9-3 KRT31 KRT35 |
| chr17 (17q12.2) | 40,750,001 | 41,250,000 | 2.51 | 0.00016288 | KRTAP3-2 KRTAP1-5 KRTAP4-6 KRTAP4-4 KRTAP4-1 KRTAP9-3 |
| chr11 (11q14.1) | 85,750,001 | 86,250,000 | 2.15 | 0.00045054 | Hs.658368 Hs.658335 Hs.656225 |
| chr19 (19q13.33) | 49,750,001 | 50,250,000 | 1.98 | 0.01225630 | AKT1S1 TBC1D17 ATF5 |