Table 3.
Results of functional enrichment analysis, performed by “ToppFun” from the “ToppGene Suite” Gene Ontology tool, of over-expressed genes (with expression ratios between 1.30 and 10.00) in the total normal thyroid vs. histologically normal thyroid adjacent to papillary thyroid carcinoma differential transcriptome map. The first 10 results of each Gene Ontology categories are listed. Complete results are provided in Supplementary Table 4.
| Gene expression ratio 1.30–10.00 | |||
|---|---|---|---|
| Genes from input | GO: molecular function | Name | p-Value |
| 148 | GO:0022838 | substrate-specific channel activity | 5.76E-09 |
| 143 | GO:0005216 | ion channel activity | 1.19E-08 |
| 155 | GO:0022803 | passive transmembrane transporter activity | 1.91E-08 |
| 154 | GO:0015267 | channel activity | 2.92E-08 |
| 294 | GO:0022857 | transmembrane transporter activity | 4.18E-08 |
| 114 | GO:0022836 | gated channel activity | 1.02E-07 |
| 256 | GO:0015075 | ion transmembrane transporter activity | 1.15E-07 |
| 14 | GO:0005132 | type I interferon receptor binding | 2.04E-07 |
| 358 | GO:0005215 | transporter activity | 3.17E-07 |
| 58 | GO:0022834 | ligand-gated channel activity | 1.52E-06 |
| Genes from input | GO: Biological process | Name | p-Value |
| 15 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein | 1.82E-06 |
| 432 | GO:0006811 | ion transport | 2.85E-06 |
| 15 | GO:0033139 | regulation of peptidyl-serine phosphorylation of STAT protein | 4.55E-06 |
| 19 | GO:0002323 | natural killer cell activation involved in immune response | 9.71E-06 |
| 38 | GO:0060349 | bone morphogenesis | 2.38E-05 |
| 22 | GO:0003009 | skeletal muscle contraction | 2.51E-05 |
| 16 | GO:0042501 | serine phosphorylation of STAT protein | 3.03E-05 |
| 21 | GO:0033275 | actin-myosin filament sliding | 3.74E-05 |
| Genes from input | GO: Cellular component | Name | p-Value |
| 422 | GO:0005615 | extracellular space | 1.14E-11 |
| 472 | GO:0031226 | intrinsic component of plasma membrane | 4.23E-09 |
| 453 | GO:0005887 | integral component of plasma membrane | 1.49E-08 |
| 297 | GO:0098590 | plasma membrane region | 1.36E-07 |
| 79 | GO:0045211 | postsynaptic membrane | 3.42E-06 |
| 97 | GO:0097060 | synaptic membrane | 1.19E-05 |
| 339 | GO:0098589 | membrane region | 1.26E-05 |
| 91 | GO:0034702 | ion channel complex | 1.15E-04 |
| 99 | GO:1902495 | transmembrane transporter complex | 2.26E-04 |
| 128 | GO:0031012 | extracellular matrix | 3.14E-04 |