Table 3.
EC(a) | #Protein Chains | #D-SRVs (b) | #N-SRVs (c) | #D-SRVs on: | #N-SRVs on: | ||
---|---|---|---|---|---|---|---|
ACTIVE SITE | BINDING SITE | ACTIVE SITE | BINDING SITE | ||||
Oxidoreductases | 64 | 1045 | 107 | 2 | 20 | 0 | 0 |
Transferases | 71 | 1058 | 122 | 5 | 20 | 0 | 0 |
Hydrolases | 69 | 1342 | 143 | 7 | 10 | 0 | 1 |
Lyases | 19 | 260 | 36 | 0 | 3 | 0 | 0 |
Isomerases | 7 | 236 | 14 | 0 | 7 | 0 | 0 |
Ligases | 11 | 138 | 15 | 0 | 7 | 0 | 2 |
Multiple ECs | 7 | 179 | 18 | 0 | 0 | 0 | 0 |
Total | 248 | 4258 | 455 | 14 | 67 | 0 | 3 |
(a) EC = enzyme commission; (b) D-SRVs = disease-related SRVs; (c) N-SRV = neutral SRVs. Residue annotation (Active site, Binding site) is taken from the corresponding protein file in UniprotKB.